A unique workshop on the topic rETHinking Drug Design with Artificial Intelligence took place in the Art Gallery "The Laundry", located in San Francisco’s exciting Mission District. Twenty senior professionals and executives from industry and academia with different backgrounds – ranging from classical medicinal chemists, physicians, and machine learners to philosophers and architects – gathered for this first-in-class event. The participants aimed to identify those challenges of the pharmaceutical design process that might benefit most from applied artificial intelligence. Cross-disciplinary thinking in an open atmosphere was stimulated and enabled by the innovative format of this workshop. The proceedings will be prominently published as a white paper.